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Lyme Disease Blog

The latest in Lyme disease treatment by Lyme Experts.

A Comprehensive Look At Natural Lyme Prevention, Proper Testing & Diagnosis + A Deep Dive Into The Science of Herbal Treatment For 2022

According to the Centers for Disease Control (CDC), Lyme disease is one of the most rapidly emerging infectious diseases in North America and Europe.

On the East coast, 50-60% of western black legged ticks are infected with species of Borrelia that cause Lyme disease.

60 of Western BlackLegged Ticks Are Infected Chart

Named after a small Connecticut town, Lyme disease is transmitted to humans by the bite of ticks infected with the bacterial spirochete Borrelia burgdorferi. To make matters worse, there are several other species of Borrelia that cause Lyme disease and tick borne relapsing fever.

Initial signs and symptoms when first infected are very similar to that of the flu, leaving many cases undetected.

When initially infected, typical signs and symptoms—including fever, body aches, fatigue, headaches, nausea, and Erythema migrans (bullseye rash)—are very similar to that of the flu and can often be dismissed as such, leading to undetected infection. 

If left untreated or improperly treated, Lyme disease can spread to the heart, joints, and nervous system, causing symptoms ranging from stiff neck, swollen joints, and muscle pain to heart palpitations, headaches, psychiatric symptoms (anxiety, depression, and aggression), irritable bladder, cognitive decline, insomnia, and night sweats.

Being Aware Is Crucial To Preventing Lyme disease.

Several factors must be taken into consideration to prevent Lyme disease:

  • Knowing where you are most likely to pick up ticks
  • How to keep your lawn and pets free of ticks
  • Preventing a bite if a tick hitches a ride on you or your children
  • Identifying the ticks that put you at most risk
  • Removing the tick promptly and properly
  • Knowing the symptoms of an infection
  • Recognizing the flaws in testing and the rate of misdiagnosis.

That's a lot of information to digest! Still, being aware of all of these factors is crucial in protecting your family.

Lyme Prevention Basics

The first step in preventing Lyme disease is something many of us learn as we begin to explore the great outdoors–avoid tick bites.

When out in grassy areas, leaves, or woods, wear long sleeved and light colored clothing, and pull your socks over your pants.

But Did you know that you don’t have to go into the woods to get ticks?

Most ticks are found within the inner three yards of your tree line.  Stone walls make perfect mice hotels, trees provide shade, and leaves provide warmth for mice and other rodents, who serve as hosts for ticks. A staggering eighty-six percent of ticks are found within this perimeter of your lawn, but leaf removal, cleaning out stone walls, and increasing sunlight past the perimeter of the lawn will decrease ticks on your property by ninety percent.

Take additional precautions by setting up your children’s swing set or play area away from the tree line in order to reduce their exposure to the area of highest tick concentration.

Natural Yard Sprays To Protect Your Home

You can also utilize natural sprays that are safe for honeybees and amphibians, as well as humans and pets, which can keep ticks at bay. 

Spraying for ticks should be done in the early spring, summer, and late fall, and should be applied to the entire lawn, well past the perimeter and into the woods. Consider recycling paper towel tubes into tick tubes that help to eliminate ticks from rodents like the white footed mouse which is the main spreader of tiny nymph ticks. 

Natural Tick Repellants To Protect Your Family

There are many natural tick sprays that do not use DEET but contain essential oil of chrysanthemum or cedar, which is effective in repelling ticks and other insects.

Insect Shield is a company that treats special clothing/gear for outside activities (hunting, fishing, rock climbing, hiking) with tick repellant and lasts seventy washes. Regardless of precautions taken, it is important to perform tick checks on yourselves, children, and pets after being outside. Pay special attention to the hair line, arm pits, belly button, back of knees, and groin.

Recognizing the types of ticks that carry Lyme disease and co-infections is also crucial.

Most people are aware that a deer tick ranges in size from a sesame seed to that of a poppy seed, while a dog tick is much larger. 

What most people do not know is that a fully engorged deer tick is the same size of a fully engorged dog tick!

Nymph ticks are harder to spot, as they are much smaller than an adult deer tick, are a translucent/pale color, and are as small as the period at the end of this sentence. It is very common to not realize that you have been bitten by a tick, and to never find the tick that transmitted Lyme disease to you. These ticks are usually hidden well enough to become fully engorged and drop off without your awareness, which is how most people contract Lyme and other co-infections.

"...less than half of people diagnosed with Lyme have a history of a known tick bite or bullseye rash."

Remember, you do not need to have found a tick on your body or to have developed Erythema migrans to be diagnosed with Lyme disease. In fact, less than half of people diagnosed with Lyme have a history of a known tick bite or bullseye rash. If you do develop any of these symptoms, talk with your doctor about proper testing, or find a Lyme literate practitioner who knows how to diagnose and treat appropriately.

"It is important to know that the lifestyle and nutritional imbalances we experience as a society create chronic, systemic, low-grade inflammation that make it harder for us to overcome infection as well (Ruiz-Nunez, 2013). As a naturopathic physician, I believe that this is where we as individuals can make the greatest difference in the fight against Lyme and tick-borne disease."

~ Dr. Myriah Hinchey

 

When we think about why Lyme disease so easily takes over the human body, we see that inflammation plays a huge role.

If the body is constantly “putting out fires” from everyday exposure to events or substances that cause inflammation (such as stress, sugar, environmental allergens, food sensitivities, chemicals, nutrient deficiencies, vitamin D3 deficiency, etc.), it has a much harder time when a real threat enters the body.

We have to focus on creating a foundation for health, which is simple but sometimes hard to implement in modern life. Rather than subscribing to a particular diet or detox to achieve this goal, I instead recommend returning to the basics. Eat food in its original unprocessed form. Limit sugar and alcohol intake. Drink fresh, filtered water as often as possible. Move your body. Create a healthy sleep schedule and take time during your day for short mental health breaks. Prioritize stress-relieving activities that bring you joy and peace. If it is too overwhelming to implement all these at once, work on one aspect of health at a time, and build upon that. It’s never too late to start improving your body’s resilience.

Taking a Bite out of Lyme. What To Do If You Are Bitten By A Tick

What if you are bitten? Do not panic, as there is plenty that both conventional and naturopathic medicine can do acutely to prevent infection from taking hold and causing illness. First things first, however, you must remove the tick safely.

Do not use anything to “suffocate” the tick, as this may cause the tick to regurgitate its contents into you and expose your body to Borrelia burgdorferi and other species of Borrelia that cause Lyme disease, as well as its co-infections. Use flat-tipped tweezers to grasp the tick at the base of the head (not the body) and slowly but firmly pull the tick from the skin in the same direction that it is implanted.

Once the tick is removed, use a clear plastic sealable bag to store it. Apply hydrogen peroxide to clean the wound. Mix bentonite clay and Andrographis tincture (an anti-spirochetal herb) to form a paste and apply it directly to the bite. Cover with a bandage soaked in the Andrographis tincture and let it heal.

The International Lyme and Associated Diseases Society (ILADS) recommends that those experiencing Erythema migrans (bullseye-rash) undergo antibiotic therapy for four to six weeks.

For those without access to antibiotics or aversion to pharmaceutical use, herbal antimicrobials taken internally can be used effectively to address the suspected infection, either instead of prescriptions or in addition to them.

A recent study looked at several antimicrobial and antiparasitic herbs as compared to the controls of prescription doxycycline and cefuroxime (Feng, 2020). The botanicals with “good” to “strong” activity against Borrelia included Cryptolepis sanguinolenta, Juglans nigra (Black walnut), Polygonum cuspidatum (Japanese knotweed), Artemisia annua (Sweet wormwood), Uncaria tomentosa (Cat's claw), Cistus incanus, and Scutellaria baicalensis (Chinese skullcap).

In fact, Cryptolepis sanguinolenta extract caused complete eradication of the spirochete, while doxycycline and cefuroxime could not fully eradicate B. burgdorferi. This research makes a powerful case for using herbal antibiotics in addition to or instead of pharmaceuticals. (Feng, 2020)

You may also consider taking homeopathic Ledum and Apis, two remedies excellent at addressing puncture wounds and insect bites and stings. Dr. Alexis Chesney, a Lyme literate Naturopathic physician, put together a very helpful Tick Preparedness Kit that contains herbs, homeopathics, and items for tick removal and storage.

The Tick Preparedness Kit has everything
you need to treat a tick bite

by Dr. Alexis Chesney

Preventing Lyme and other tick borne diseasesAs described in the book Preventing Lyme and Other Tick-Borne Diseases by Alexis Chesney ND. 
*Book sold separately

  • Tick Twister by O’Tom (there are other tools for removing ticks, but this one is my favorite and, in my experience, the most effective)
  • Small ziplock bag (for collecting the tick)250w Tick Preparedness Kit
  • Andrographis tincture with dropper
  • Homeopathic Ledum palustre 30C
  • Homeopathic Apis mellifica 30C
  • 4 ounce Deer Tick Bite Formula

*4 ounce tick bite prophylactic formula specific to the types of ticks in your region (default Deer Tick Bite Formula) 

Dr. Chesney's New Tick Kit...

 

Test Your Ticks–and Yourself

I recommend sending the tick for testing so that your practitioners can help you create a treatment plan tailored to the specific pathogens that are found in the tick. 

Although there are inexpensive and even free resources for tick testing, I have found the most comprehensive way to test ticks is using the expanded panel through www.tickreport.com. The results typically come back within 48-72 hours, which allows for timely and proper antibiotic treatment.

Ticks can carry parasites and viruses as well!

A study published in 2020 found that Ixodes scapularis, or blacklegged deer ticks, are the most common ticks in Connecticut. These ticks carry multiple bacteria that can cause Lyme disease, and several others that cause co-infections like Anaplasma phagocytophilum, Babesia microti, Bartonella henselae, and Borrelia miyamotoi (Pokutnaya, 2020).

This means that a tick bite puts you at risk for a multitude of diseases, so it is essential that the tick testing you choose is comprehensive. It is best to know what infections the tick itself carried and choose the appropriate antibiotics or antiparasitics (prescription or herbal) that can treat them.

The Controversy of Lyme Diagnosis

Diagnosis of Lyme disease is surprisingly controversial. Testing for Lyme and co-infections is complicated, and in acute cases, it can lead to false negative results that cause misdiagnosis and allow the disease to become chronic.

Standard testing involves a two tiered test: first, an ELISA is used to detect antibodies and if it is found positive, a Western Blot is performed to confirm the initial diagnosis. The problem with this testing technique is that the ELISA is not a sensitive test, especially during the first few months of infection.

The 2 Tiered Testing for Lyme Disease is positive in less than 30-60% of patients infected with Lyme disease.

2 Tiered Testing For Lyme Disease by the CDC

The MarDX Western Blot (which tests for ONLY Borrelia burgdorferi species and is used by most standard laboratories) is much more sensitive than the ELISA and detects Borrelia burgdorferi more often, but can still give a false negative more than 30% of the time.

In addition to issues with test sensitivity, there is the matter of timing. It can take weeks for IgM to become positive and over a month for IgG to show a Lyme infection, so testing too soon after a tick bite may not be accurate (CDC, 2021).

If a patient is not mounting a strong immunological response to Lyme, it is hard to detect antibodies in the patient’s blood, which is what ELISA and Western Blot testing investigate. Performing a urine PCR, which looks for DNA of Borrelia burgdorferi, is more accurate. 

To complicate matters further, if you are only looking at Borrelia burgdorferi, you will miss the presence of other species of Borrelia that cause Lyme disease and TBRF.

Antibody and PCR testing does not test for co-infections, so you may receive a false negative, despite clinically showing signs of infection. For these reasons, it is important to be tested for all of the common co-infections of Lyme disease, including Babesia, Mycoplasma, Bartonella, Anaplasma, and Ehrlichia, none of which are detected by any Lyme test.

Once again, being proactive and treating comprehensively is the best approach.

Specialized laboratories like IGeneX or Vibrant Wellness can be used for proper testing of all tick-borne diseases.

 864x374Lymecore Botanicals herbal supplements 166117859

An Unusually Natural Way of Doing Things.
The Science Behind The Herbs

Before we dive into natural interventions that are useful to treat and heal Lyme disease, it is extremely important to understand how Lyme develops.

In a fascinating study published in 2019, researchers in Amsterdam found that tick saliva is not only the medium through which the pathogenic bacteria enter their hosts, it also contains a mixture of proteins that disarm the body’s immune system. This protects Borrelia from any natural defenses that you would normally mount to infection (Nuttall, 2019).

We have also learned that once a tick bites, the saliva further decreases normal immune function by slowing blood coagulation and other aspects of wound healing.

This way, the tick can continue to feed for a longer period, while also transmitting higher loads of Borrelia in the process (Pham, 2021). Together, the tick saliva and Borrelia further manipulate the biochemistry of the body to degrade connective tissue. Collagen is rich in nutrients that nourish Borrelia, so the bacteria tends to migrate to areas high in collagen–like joints– in order to feed themselves and reproduce (Zambrano, 2004). This ultimately makes the collagen-dense connective tissue in the body an ideal place to host bacteria and let Lyme disease thrive.

An Herbal Arsenal

Because of the complexity of spirochetal infection, prescription antibiotics may not be a cure-all for Lyme disease.

When we focus simply on killing a pathogen, we miss the opportunity to bolster the body’s own defense mechanisms. As a licensed Naturopathic physician, I believe in utilizing a comprehensive approach to Lyme disease, attacking the pathogen at every step, while also supporting the body’s innate healing wisdom with whole plant medicines.

"My focus is making the body inhospitable to the infection while healing the body."

~ Dr. Myriah Hinchey               

Addressing the immune system imbalance that the proteins in tick saliva create as well as inhibiting movement of the infection is a crucial step in treatment.

Withania somnifera (Ashwagandha) counteracts the exact modulation of the immune system that tick saliva and pathogens initiate and maintain to keep infection going (Bani, 2006).

One of the immune molecules that spirochetes alter in the body is NF-kB (Nuclear Factor Kappa Beta), which feeds inflammation. Spirochetes stimulate NF-kB to drive inflammation, breaking down tissues from which they need to feed (Parthasarathy, 2014).

Inhibiting NF-kB to prevent excessive inflammation is a very important goal in pharmaceutical drug development, as this pathway affects many other inflammatory diseases as well, including various cancers, COVID-19, and Alzheimer’s disease. Luckily, this is where herbalism shines.

Among the masses of botanicals that are available to the general public, there are a good number of herbs that show NF-kB inhibiting properties and have the scientific research to back them up. Among my favorites are Astragalus membranaceus, a legume that has been used in Traditional Chinese Medicine for centuries, most notably as a general immune system enhancer.

A 2020 study showed that the herb alleviates inflammation specifically through the NF-kB pathway (Dong, 2020). Astragalus also has the benefit of being an adrenal adaptogen, balancing the body’s stress response and fighting fatigue (Huang, 2021).

Another natural remedy which you may have seen at your local health foods store is Cordyceps militaris, a type of fungus that has been historically used in folk medicine to improve immune function.

Its ability to modulate NF-kB was identified in the 2000s, and a recent study from China showed that different preparations of the fungus (water, 50% ethanol, or 70% ethanol extract preparations) could encourage the immune system to operate in different ways (Lee, 2020). This is a tremendous development in the individualized approach to healing Lyme disease, as different people will need different aspects of their immunity adjusted to effectively eradicate the infection. In addition to its anti-inflammatory actions, this botanical reduces fatigue (Song, 2015) and is a potent antioxidant (Rupa, 2020). 

There are a multitude of other medicinal herbs that I combine to naturally treat Lyme disease and co-infections but the last I will discuss in this article contains high levels of resveratrol; helpful for relieving Lyme-associated inflammation. 

Resveratrol (a flavonoid found in foods like grapes, wine, peanuts, and soy), is highly concentrated in an herb called Japanese knotweed, Polygonum cuspidatum.  Not only does Japanese knotweed stop the inflammatory NF-kB cascade (Diaz-Gerevini, 2016), it also inhibits the growth of Spirochetes at several different developmental stages of the parasite (Feng, 2020). Lastly, resveratrol is highly neuroprotective, which can be very helpful for the brain fog associated with Lyme infection (Wiciński, 2020).

Putting It All Together

The biggest challenge for those battling Lyme disease and co-infections, whether it is a new diagnosis or a recurring chronic case, is knowing how to move forward.

Patients are constantly bombarded with either apathy about their situation or unsolicited advice on how to deal with it. Family, friends, teachers and even doctors seldom understand the multi-system dysfunction and the serious emotional toll Lyme disease takes on the patient. Patients can be left feeling hopeless, confused and alienated, and are often told it is all in their head and prescribed antidepressants.

I completely understand!

As a fellow Lyme warrior myself, I have made it my mission as a physician to make sure my patients (and their families, teachers and doctors) understand how Lyme develops and becomes a chronic infection, how to make their body inhospitable to the infection, how to bolster the body’s innate ability to heal itself, and ways to weave both conventional and natural medicine interventions together in order to fully recover from this destructive inflammatory infection. With all of that said, here is a summary of my advice.

 

Early Detection & Immediate Prevention Is key!

Begin by making your environment and your body inhospitable to ticks and the pathogens they harbor.

  • Perform tick checks on yourself and your children daily.
  • If you find a tick, properly remove it, send it off for testing.
  • Immediately, begin prophylactic herbal immune balancers, herbal anti- inflammatories, and herbal antimicrobials to prevent infection of the pathogens that cause Lyme disease and co-infections.
  • When you receive the tick testing results, add the proper prescription antibiotics or antiparasitics if necessary while remaining on the herbals.

Continue this for four to six weeks or as prescribed by your physician, and seek the care of a qualified Lyme literate specialist for further guidance.

 

SUMMARY: Healing Chronic Lyme Naturally For 2022, Is All About Back-To-Basics Immune System Care

As I mentioned before, a rock-solid foundation for health is essential to a properly functioning immune system.

Continually work to achieve proper nutrient levels by eating nutrient dense foods and avoid those that are processed and filled with sugar; drink an adequate amount of water; get enough rest; and manage your stress in order to support normal and healthy inflammatory responses.

Naturopathic physicians are incredible resources for those interested in making lifestyle changes to support health and wellness, and we are fortunate enough to live in a state where naturopathic medicine is covered by most major medical insurances.

Take advantage of the knowledge and support of a qualified Lyme literate physician (ILADS.org) along your Lyme journey. It can make all the difference!

About the Author

Myriah Headshot Tao 500wIn addition to naturally treating patients with complex illness stemming from underlying tick-borne disease at TAO in Connecticut, Dr. Myriah Hinchey created LymeCore Botanicals™ to provide quality clean and effective herbal formulas for Lyme disease and other tick-borne infections, and is highly active in sourcing, testing, and overseeing production of the herbal formulas she uses to treat her patients. 

Dr. Hinchey also founded LymeBytes™, a multimedia company dedicated to educating patients and other practitioners about Lyme disease and tick-borne illness and focuses on bringing Patients, Practitioners and Resources together for healing Lyme disease.

LymeBytes™ is hosting its first Symposium on May 21-22 at the Mohegan Sun Casino in Uncasville, CT (live virtual attendance is also available).

FINAL v04 Horizontal LymeBytes Symposium Logo

Check Out Our Great Line Up of Lyme Expert Speakers!

May 21st is just around the corner! Limited in-person seats still available.

Don't loose your seat. REGISTER NOW!

*All registrations (in-person & virtual) will have access to video & slides after the event through our event app

References

Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Vector-Borne Diseases (DVBD). (2021, January 8). Diagnosis, Testing, and Treatment. https://www.cdc.gov/lyme/faq/index.html 
Bani S, Gautam M, Sheikh FA, Khan B, Satti NK, Suri KA, Qazi GN, Patwardhan B. Selective Th1 up-regulating activity of Withania somnifera aqueous extract in an experimental system using flow cytometry. J Ethnopharmacol. (2006, Aug 11);107(1):107-15. doi: 10.1016/j.jep.2006.02.016. Epub 2006 Apr 5. PMID: 16603328. https://pubmed.ncbi.nlm.nih.gov/16603328/
Diaz-Gerevini, G. T., Repossi, G., Dain, A., Tarres, M. C., Das, U. N., & Eynard, A. R. (2016). Beneficial action of resveratrol: How and why?. Nutrition (Burbank, Los Angeles County, Calif.), 32(2), 174–178. https://doi.org/10.1016/j.nut.2015.08.017
Dong, N., Li, X., Xue, C., Zhang, L., Wang, C., Xu, X., & Shan, A. (2020). Astragalus polysaccharides alleviates LPS-induced inflammation via the NF-κB/MAPK signaling pathway. Journal of cellular physiology, 235(7-8), 5525–5540. https://doi.org/10.1002/jcp.29452
Feng, J., Leone, J., Schweig, S., & Zhang, Y. (2020). Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi. Frontiers in medicine, 7, 6. https://doi.org/10.3389/fmed.2020.00006
Huang, W. Y., Youk, J. S., Han, B. K., Heo, W., Yun, B. S., Kim, J. S., Koo, Y. T., Hwang, K. A., Yoon, J. A., & Kim, Y. J. (2021). Improvement of Fatigue Symptoms and Endurance Capacity by the Combined Administration of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge. Journal of medicinal food, 24(6), 577–585. https://doi.org/10.1089/jmf.2020.4743
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Nuttall P. A. (2019). Tick saliva and its role in pathogen transmission. Wiener klinische Wochenschrift, 10.1007/s00508-019-1500-y. Advance online publication. https://doi.org/10.1007/s00508-019-1500-y
Parthasarathy, G., & Philipp, M. T. (2014). The MEK/ERK pathway is the primary conduit for Borrelia burgdorferi-induced inflammation and P53-mediated apoptosis in oligodendrocytes. Apoptosis : an international journal on programmed cell death, 19(1), 76–89. https://doi.org/10.1007/s10495-013-0913-8
Pham, M., Underwood, J., & Oliva Chávez, A. S. (2021). Changing the Recipe: Pathogen Directed Changes in Tick Saliva Components. International journal of environmental research and public health, 18(4), 1806. https://doi.org/10.3390/ijerph18041806
Pokutnaya, D., Molaei, G., Weinberger, D. M., Vossbrinck, C. R., & Diaz, A. J. (2020). Prevalence of Infection and Co-Infection and Presence of Rickettsial Endosymbionts in Ixodes Scapularis (Acari: Ixodidae) in Connecticut, USA. The Journal of parasitology, 106(1), 30–37.
Ruiz-Núñez, B., Pruimboom, L., Dijck-Brouwer, D. A., & Muskiet, F. A. (2013). Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context. The Journal of nutritional biochemistry, 24(7), 1183–1201. https://doi.org/10.1016/j.jnutbio.2013.02.009
Rupa, E. J., Li, J. F., Arif, M. H., Yaxi, H., Puja, A. M., Chan, A. J., Hoang, V. A., Kaliraj, L., Yang, D. C., & Kang, S. C. (2020). Cordyceps militaris Fungus Extracts-Mediated Nanoemulsion for Improvement Antioxidant, Antimicrobial, and Anti-Inflammatory Activities. Molecules (Basel, Switzerland), 25(23), 5733. https://doi.org/10.3390/molecules25235733
Song, J., Wang, Y., Teng, M., Cai, G., Xu, H., Guo, H., Liu, Y., Wang, D., & Teng, L. (2015). Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence-based complementary and alternative medicine : eCAM, 2015, 174616. https://doi.org/10.1155/2015/174616
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Wiciński, M., Domanowska, A., Wódkiewicz, E., & Malinowski, B. (2020). Neuroprotective Properties of Resveratrol and Its Derivatives-Influence on Potential Mechanisms Leading to the Development of Alzheimer's Disease. International journal of molecular sciences, 21(8), 2749. https://doi.org/10.3390/ijms21082749 

Zambrano, M. C., Beklemisheva, A. A., Bryksin, A. V., Newman, S. A., & Cabello, F. C. (2004). Borrelia burgdorferi binds to, invades, and colonizes native type I collagen lattices. Infection and immunity, 72(6), 3138–3146. https://doi.org/10.1128/IAI.72.6.3138-3146.2004